The following organizations endorsed the 2012 NSSME:
- American Association of Physics Teachers
- American Chemical Society, Education Division
- American Federation of Teachers
- Association of Mathematics Teacher Educators
- Association of State Supervisors of Mathematics
- Center for the Study of Mathematics Curriculum
- Council of State Science Supervisors
- National Association of Biology Teachers
- National Association of Elementary School Principals
- National Association of Secondary School Principals
- National Catholic Education Association
- National Council of Supervisors of Mathematics
- National Council of Teachers of Mathematics
- National Earth Science Teachers Association
- National Education Association
- National School Boards Association
- National Science Education Leadership Association
- National Science Teachers Association